TDP-43-binding polypeptides useful for the treatment of neurodegenerative diseases
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Feb 12, 2019
Grant Date -
Dec 14, 2017
app pub date -
Dec 7, 2015
filing date -
Dec 5, 2014
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
Provided herein are antigen-binding constructs such as antibodies that bind to the RRM-1 domain of TDP-43. The antigen-binding constructs are capable of blocking the interaction of TDP-43 with NF-κB in cells. Also provided herein are method of using the antigen-binding constructs in the treatment of diseases associated with TPD-43 proteinopathy, such as amyotrophic lateral sclerosis (ALS), frontotemperal lobar degeneration (FTLD), Lewy body disease and motor neuron disease.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully