TFPI inhibitors and methods of use

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United States of America Patent

PATENT NO 10201586
APP PUB NO 20170157198A1
SERIAL NO

15373742

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Abstract

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The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify TFPI, an identify a TFPI-binding compound.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSASKA-SHI OSAKA 541-0045

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dockal, Michael Vienna, AT 47 164
Ehrlich, Hartmut Paris, FR 46 206
Fries, Markus Vienna, AT 5 27
Hartmann, Rudolf Bisamberg, AT 31 298
Osterkamp, Frank Berlin, DE 31 175
Polakowski, Thomas Berlin, DE 19 110
Reineke, Ulrich Berlin, DE 34 219
Scheiflinger, Friedrich Vienna, AT 107 597

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