Human pancreatic beta cell lines for diagnostic of diabetes
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United States of America Patent
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Jan 1, 2019
Grant Date -
Dec 29, 2011
app pub date -
Feb 21, 2008
filing date -
Feb 21, 2007
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Abstract
The present invention relates to a method for preparing commercial scale quantities of human functional Betacells and to the establishment of cell lines. It also relates to a method of diagnosis using Beta cell tumors or cells derived thereof. The method comprises sub-transplantation procedure to enrich the graft in proliferating Betacells, allowing to generate human Betacell lines. Such lines express little amount of insulin and have a gene expression profile that resembles to adult Betacells. In addition, the human Betacell lines are able to normalize glycemia of diabetic mice when transplanted, demonstrating their insulin secretion capabilities.
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