Activated sialic acid derivatives for protein derivatisation and conjugation
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United States of America Patent
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Dec 18, 2018
Grant Date -
May 5, 2016
app pub date -
Dec 19, 2015
filing date -
Feb 23, 2005
priority date (Note) -
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Abstract
Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.
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International Classification(s)
- A61K:PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOS....
- C07H:SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTI....
- C08H:DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C12P:FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESI....
- C12N:MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF
- C08B:POLYSACCHARIDES; DERIVATIVES THEREOF
- C07K:PEPTIDES
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