Nargenicin compounds and uses thereof as antibacterial agents
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United States of America Patent
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Dec 4, 2018
Grant Date -
Jul 5, 2018
app pub date -
Mar 2, 2018
filing date -
Oct 22, 2014
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Abstract
The present invention relates to novel nargenicin related compounds which can inhibit DnaE and have antibacterial, particularly antimycobacterial activity against Mycobacterium tuberculosis. The present invention also relates to method for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis by administering an antimycobacterially effective amount of nargenicin or a nargenicin-related compound and/or their pharmaceutically acceptable salts.
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