Methods of aiding in the diagnosis of diseases using anti-IL-6 antibodies
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United States of America Patent
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Nov 6, 2018
Grant Date -
Apr 27, 2017
app pub date -
Sep 26, 2016
filing date -
Nov 25, 2008
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Abstract
The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.
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