Apatite in-situ restoration

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 10099157
APP PUB NO 20150367252A1
SERIAL NO

14747221

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Abstract

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Disclosed are compositions and methods for regenerating or reducing the deterioration of an apatite solid surface during, or subsequent to, a chromatographic procedure for purifying a target molecule from a sample, by treating the apatite solid surface with a buffered calcium solution, followed by a phosphate buffered solution, followed by an alkaline hydroxide. The buffered calcium solution, phosphate buffered solution, and alkaline hydroxide can be applied subsequent to a bind and elute or flow through purification procedure. The methods provide an increase in resin mass and/or particle strength compared to prior methods.

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Patent Owner(s)

Patent OwnerAddress
BIO-RAD LABORATORIES INC1000 ALFRED NOBEL DRIVE HERCULES CA 94547

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Brisack, Kimberly C San Francisco, US 1 9
Snyder, Mark A Oakland, US 22 221

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