Method for preparing peptides by assembling multiple peptide fragments

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United States of America Patent

PATENT NO 10072041
APP PUB NO 20130331545A1
SERIAL NO

13985369

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Abstract

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Method for preparing a peptide assembly of n fragments and n−1 amino acids bearing a thiol function, represented by the formula:

description='In-line Formulae' end='lead'A1-C1-A2-C2-A3- . . . -Ci−1-Ai- . . . -Cn−1-An  (I)description='In-line Formulae' end='tail'

in which A1, A2, A3, . . . Ai . . . , An are peptide fragments, C1, C2, C3 . . . Ci−1 . . . Cn−1 are amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A1-SR (II) in which A1 is a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.

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Patent Owner(s)

Patent OwnerAddress
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEPARIS FRA
UNIVERSITE DE LILLE 1 SCIENCES ET TECHNOLOGIESFRENCH ASCQ VILLENEUVE D'ASCQ NORD

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dheur, Julien La Bassee, FR 2 5
Melnyk, Oleg Annoeullin, FR 15 37
Mhidia, Reda Mons en Baroeul, FR 2 5
Ollivier, Nathalie Roubaix, FR 6 11

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