Chiral N-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists, pharmaceutical composition, methods for use in NK-3 receptor mediated disorders and chiral synthesis thereof

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United States of America Patent

PATENT NO 10065961
APP PUB NO 20170029429A1
SERIAL NO

15259922

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Abstract

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The present invention relates to novel compounds of Formula I and their use in therapeutic treatments. The invention further relates to a novel chiral synthesis of 5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines using N-sp3 protective groups. The invention also provides intermediates for use in the synthesis of compounds of Formula I.

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Patent Owner(s)

Patent OwnerAddress
OGEDA SARUE ADRIENNE BOLLAND 47 CHARLEROI 6041

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Batt, Frederic Lyon, FR 4 21
Bousmaqui, Mohamed E Aul-Noy-lez-Valenciennes, FR 1 2
Dutheuil, Guillaume Vedrin, BE 30 141
Fraser, Graeme L Bousval, BE 21 396
Hoveyda, Hamid R Brussels, BE 42 506
Roy, Marie-Odile Paris, FR 11 80

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