Implantable bio-resorbable polymer charged with fragile macromolecules
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United States of America Patent
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Sep 4, 2018
Grant Date -
Dec 26, 2013
app pub date -
Mar 9, 2012
filing date -
Mar 9, 2011
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Abstract
The present invention relates to a macromolecule-loaded bioresorbable crosslinked polymer wherein the polymer is obtainable from the polymerization of: (i) at least one monomer of formula (I) (CH2═CR1)CO—K wherein: —K represents O—Z or NH—Z, Z representing (CR2R3)m—CH3, (CH2—CH2—O)m—H, (CH2—CH2—O)m—CH3, (CH2)m—NR4R5 with m representing an integer from 1 to 30; —R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; and (ii) at least one bio-resorbable block copolymer cross-linker, and wherein the macromolecule is chosen in the group consisting of proteins and nucleic acids.
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